Question under study:Over the last decade the Swiss health care system has undergone several changes, resulting in stronger economic constraints, heavier administrative workload and limited work autonomy for doctors.In this context we examined the change in burnout prevalence over time among Swiss doctors surveyed during this period.Methods:Cross-s
Abstract Manufacturing autologous chimeric antigen receptor (CAR) T cell therapeutics is complex, and many patients experience treatment delays or cannot be treated at all.Although current allogeneic CAR products have the potential to overcome manufacturing bottlenecks, they are subject to immune rejection and failure to persist in the host, and th
Based on preliminary developed treatment of obtaining blocks of double base propellants, examinations of internal-ballistics and mechanical characteristics of propellants with and without metallic conductors of wire configuration have been performed.Internal-ballistics examinations have been done in the Crawford-s bomb and an experimental motor.Fro
Biological structural systems such as plant seedcoats, beak of woodpeckers or ammonites shells are characterized by complex wavy and re-entrant interlocking features.This allows to mitigate large deformations and deflect or arrest cracks, providing remarkable mechanical performances, much higher than those of the constituent materials.Nature-inspir